Targeted and Systemic Delivery

Most traditional medicines are given orally, topically or by injection.  While dry powders can be used in these applications, they also can be inhaled into the lungs for targeted or systemic delivery.  

There are a vast number of targeted applications including the delivery of anti-inflammatory agents to the constricted airways of asthmatics, vaccines for the prevention of disease, or antibiotics to the site of infection in patients with pneumonia.  In all these cases the use of dry powders offer significant advantages compared to traditional medicine because the targeted delivery can lead to dose sparing and minimization of side-effects.  

The human lungs have a surface area roughly equal to that of a tennis court to aid in the exchange of oxygen and carbon dioxide gas to and from the blood.  This fact, combined with the incredible perfusion of each alveolus, make the lungs an ideal location for the delivery of drugs whose target is the systemic circulation.  In addition, first pass elimination is avoided, potentially leading to dose minimization and a reduction in toxicity and side-effects.

The traditional dry powder manufacturing methods of lyophilization and spray drying do not produce particles with consistent aerodynamic properties amenable for targeted or systemic delivery.  With ASFD, engineered particles with consistent spherical shape and size mean more of the drug gets to its intended delivery location.  The ASFD particles also have high surface areas that allow them to dissolve fast before the body’s clearance mechanisms clear them from the system.